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Analysis of Co-aggregation of Cancer Based on Registry Data

by A. Matthews et al.
Questions regarding this item should be sent to Dianne Finkelstein.

We conducted an exploratory analysis of co-aggregation of cancers in individuals and families utilizing sibships from over 18,000 families who had been recruited to the registry of the NCI-sponsored multi-institutional Cancer Genetics Network. We found statistically significant familial co-aggregation of lung cancer with pancreatic (p<0.0001), prostate (p < 0.001), and colorectal cancers (p=0.003). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (p=0.022), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (p=0.01)